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Contraindicated (1)pentobarbital will reduce the level or effect of dienogest/estradiol valerate by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Contraindicated. Gals should not select estradiol valerate/dienogest as their contraceptive even though utilizing strong CYP3A4 inducers due to possible lessen in contraceptive efficacy.Keep an e